[Pregabalin as a probable cause of thrombocytopenia: presentation of two clinical cases and review of literature].

Pregabalin (PGB) is a psychoactive drug, approved by the FDA (Food and Drugs Administration) for neuropathic pain associated with peripheral diabetic neuropathy, for postherpetic neuralgia, for epilepsy as combined therapy in adults with partial seizures and for fibromyalgia.1 PGB has also been approved by the European Medicines Agency (EMA) for the treatment of generalized anxiety disorder.2-4 A number of studies have demonstrated the efficacy of this drug in other conditions such as benzodiazepine and alcohol dependency,5-7 post-traumatic stress disorder8 or social phobia disorder.9 Clinical use of the drug is also common outside the approved indications, such as treatment of insomnia and a range of different anxiety disorders.10-12 Prescription is therefore both promising and controversial, due to issues such as toxicity or potential abuse in patients at risk of substance dependency.13